Claude Skills by KalarisLabs

Adds runtime safety rails to LLM applications with NVIDIA NeMo Guardrails, configured through Colang 2.0 flows. Covers jailbreak and prompt-injection detection, self-check input/output validation, retrieval-based fact-checking, hallucination detection, PII filtering via Presidio, toxicity detection via ActiveFence, and LlamaGuard integration. Use when adding programmable safety rules to a production LLM app, blocking jailbreaks or prompt injection, filtering PII from model inputs and outputs,...

Create, analyze, and visualize complex networks and graphs in Python with NetworkX. Use when working with network/graph data structures, computing graph algorithms (shortest paths, centrality, clustering), detecting communities, generating synthetic networks (random, scale-free, small-world), reading/writing graph file formats, or drawing network topologies. Common applications include social, biological, transportation, and citation networks.

Use NeuroKit2 to build or audit reproducible research workflows for physiological time-series preprocessing, event/interval analysis, multimodal alignment, variability, and complexity. Trigger when code imports neurokit2 or needs its current APIs, schemas, and method-aware validation—not for diagnosis or device validation.

Analyze Neuropixels extracellular recordings end-to-end with SpikeInterface. Covers loading SpikeGLX/Open Ephys/NWB data, preprocessing, drift/motion correction, Kilosort4 (and CPU) spike sorting, quality metrics, and unit curation (threshold-based, model-based UnitRefine, and AI-assisted visual review). Use when working with Neuropixels 1.0/2.0 recordings, spike sorting, or extracellular electrophysiology analysis.

Build, run, and debug Nextflow data pipelines and nf-core workflows end to end. Use whenever the user mentions Nextflow, nf-core, .nf files, nextflow.config, DSL2, processes/channels/operators, samplesheets, or wants to run a community pipeline (e.g. nf-core/rnaseq, nf-core/sarek), write or test a module/subworkflow with nf-test, configure executors/containers (Docker, Singularity/Apptainer, Conda, Wave), scale a workflow to HPC/SLURM or cloud (AWS Batch, Google Batch, Azure, Kubernetes), or ...

Provides guidance for interpreting and manipulating neural network internals using nnsight with optional NDIF remote execution. Use when needing to run interpretability experiments on massive models (70B+) without local GPU resources, or when working with any PyTorch architecture.

Securely inspect and automate microscopy data workflows against OMERO.server with omero-py, BlitzGateway, OMERO CLI, tables, annotations, ROIs, rendering, and documented OMERO.web APIs. Use for scoped OMERO inventory, metadata export, import/export planning, or reviewed write workflows.

'Query the 1000 Genomes Project dataset (3,202 whole-genome-sequenced individuals, GRCh38) at the level of individual participants. Use when a question is about individuals or variants in the 1000 Genomes Project cohort: which individuals carry variants matching specific criteria in a gene or region, which individuals are homozygous-reference at a position, which variants exist in the dataset or carried by specified individuals in a gene or region, the relatedness between two specified indivi...

Resolve free-text scientific labels to ontology term IDs and validate existing CURIEs against the EBI Ontology Lookup Service (OLS4). Also look up prefixes in Bioregistry, resolve compact identifiers via Identifiers.org, map lab shorthand with ZOOMA, and build Ontobee term pages. Use whenever an ontology identifier must be produced or checked - annotating tissue, cell type, disease, phenotype, assay, chemical, organism, sex, or developmental stage fields; preparing metadata for GEO, ENA, BioS...

Self-hosted, open-source alternative to Google NotebookLM for AI-powered research and document analysis. Use when organizing research materials into notebooks, ingesting diverse content sources (PDFs, videos, audio, web pages, Office documents), generating AI-powered notes and summaries, creating multi-speaker podcasts from research, chatting with documents using context-aware AI, searching across materials with full-text and vector search, or running custom content transformations. Supports ...

Particle Image Velocimetry (PIV) analysis with OpenPIV. Use when extracting velocity fields from PIV image pairs, analyzing fluid dynamics or flow visualization experiments, cross-correlating interrogation windows, validating and replacing spurious PIV vectors, or computing vorticity, strain rate, and turbulence statistics from measured velocity fields.

High-performance RLHF framework with Ray+vLLM acceleration. Use for PPO, GRPO, RLOO, DPO training of large models (7B-70B+). Built on Ray, vLLM, ZeRO-3. 2× faster than DeepSpeedChat with distributed architecture and GPU resource sharing.

Author, review, migrate, simulate, and troubleshoot official Opentrons Python Protocol API v2 protocols for Flex and OT-2 robots. Use for robot-specific liquid handling, deck and labware setup, pipettes, modules, runtime parameters, liquid classes, and Opentrons App analysis. Use pylabrobot instead when one workflow must support multiple robot vendors.

GPU-accelerates scientific Python on NVIDIA hardware and verifies that the result is correct and faster. Use for CUDA/GPU optimization; CPU-bound NumPy, SciPy, pandas, scikit-learn, NetworkX, scikit-image, vector-search, image-processing, graph, simulation, or file-I/O workloads; CuPy, cuDF, cuML, cuGraph, cuVS, cuCIM, KvikIO, Warp, Newton, Numba-CUDA, or RAFT questions; and profiling, memory-transfer, kernel, or multi-GPU bottlenecks. Also use when large data-parallel Python code is slow and...

Enables Flash Attention for transformer models using PyTorch native scaled_dot_product_attention (PyTorch 2.2+) or the flash-attn library, including multi-query attention, sliding window attention, and FP8 on H100 (FlashAttention-3). Covers profiling speedup, checking accuracy against a baseline, and troubleshooting install and GPU support errors. Use when training or running transformers on long sequences (over 512 tokens), when standard attention runs out of GPU memory, when attention is th...

Generates guaranteed-valid structured output from LLMs with Outlines (dottxt.ai), constraining token sampling via finite state machines for JSON schemas, Pydantic models, regex, choice lists, and integer/float types, on Transformers, llama.cpp, vLLM, and limited OpenAI backends. Use when you need output that always parses as valid JSON or matches a regex. Use when extracting typed data into Pydantic models from a local model. Use when classifying text into a fixed set of categories. Use when ...

Operator toolkit for nf-core/pacsomatic matched tumor-normal workflows from BAM inputs. Use this skill when the user needs to validate run inputs, generate pacsomatic-compliant samplesheets, prepare reproducible Nextflow launch artifacts, run locally or submit to schedulers (LSF/Slurm/PBS/SGE), and triage execution failures. Triggers on requests to run pacsomatic, prepare launch commands/scripts, perform dry-run checks, or troubleshoot pipeline startup and scheduler submission errors.

Build grounded question answering and retrieval-augmented generation (RAG) over your own collection of research papers, with answers that cite the exact paper and passage. Use when a user wants to "chat with" or search a folder of PDFs, synthesize evidence across a literature corpus, find which paper says X, or build a vector/hybrid index with SQLite FTS5, pgvector (Postgres), Chroma, Qdrant or FAISS. Includes a zero-dependency local full-text index with citable hits.

Search 18 scholarly APIs for papers, preprints, citations, open-access full text, repository records, and journal OA status, and return results with reproducible provenance. Covers PubMed, PMC, Europe PMC, bioRxiv, medRxiv, arXiv, OpenAlex, Crossref, Semantic Scholar, CORE, Unpaywall, OpenCitations, PubTator3, Zenodo, Figshare, ROR, BioStudies, and DOAJ. Use when searching for papers, citations, DOI/PMID/arXiv lookups, abstracts, full text, open-access PDFs, preprints, citation graphs, author...

Search and read full-text biomedical papers, FDA/PMDA/EMA regulatory documents, clinical trial registries, and UniProt/PDB/ChEMBL entries with the Paperclip CLI from GXL. Covers installing and authenticating the `paperclip` binary with a PAPERCLIP_API_KEY, the read-only virtual filesystem under /papers, /fda, /trials, /proteins and /clipboard, source-scoped semantic search, corpus-wide grep, metadata lookup and SQL, map/reduce reading across many papers, figure vision analysis, opt-in paper r...

Chat with your agent about projects, recommendations, and canonical papers in Paperzilla. Use when users ask for recent project recommendations, canonical paper details, markdown-based summaries, recommendation feedback, feed export, or Atom feed URLs.

Runs the parallel-cli tool for web workflows: web search, URL and PDF extraction, deep research reports, structured data enrichment of supplied rows, FindAll entity discovery, and recurring web monitors. Prefers primary literature and institutional sources for scientific queries. Use when looking up current web evidence or a bounded research question. Use when fetching content from a known URL, PDF, or JavaScript-rendered page. Use when adding web-sourced fields to a list of companies, people...

Covers local, research-only computational pathology with PathML 3.0.5: loading and tiling whole-slide images (OpenSlide, Bio-Formats), preprocessing and QC pipelines run via SlideData.run(), .h5path data management, multiplex image quantification, spatial graph construction (KNN, RAG, HACT), and bounded local ONNX model inference planning. Use when loading or tiling slides, building tissue-mask or stain pipelines, managing .h5path files and patient-level splits, quantifying CODEX or Vectra mu...

Query live pathogen genomic surveillance data through the GenSpectrum LAPIS API to find which viral lineages are circulating now, how fast they are growing, and what mutations they carry. Use whenever a question depends on the current state of a pathogen population rather than on remembered facts - which SARS-CoV-2 variant is dominant, whether a Pango lineage is still designated or has been withdrawn, what clade or genotype of H5N1 is in a host or region, whether a PCR primer or assay target ...

Run pathway and gene-set enrichment analysis on gene lists or ranked gene data, then interpret the results. Use whenever the user has a set of genes (differentially expressed genes from PyDESeq2/Scanpy, CRISPR-screen hits, cluster marker genes, proteomics hits) and wants to know which biological pathways, GO terms, or gene sets are over-represented or enriched. Covers over-representation analysis (ORA / Enrichr / Fisher / hypergeometric), ranked Gene Set Enrichment Analysis (GSEA / preranked)...

Prepare evidence-bounded, constructive peer-review drafts and structured manuscript assessments. Use for authorized review of scientific manuscripts, protocols, preprints, or research proposals; reporting-guideline selection; claim–evidence checks; methods, statistics, reproducibility, ethics, figure/table, and citation critique; or revision-response planning.

Fine-tunes LLMs with Hugging Face PEFT, using LoRA, QLoRA, IA3, AdaLoRA, prefix tuning, and prompt tuning so that under 1% of parameters are trained. Covers rank, alpha, and target module selection, loading and merging adapters, multi-adapter serving, and integration with TRL SFTTrainer, Axolotl, and vLLM. Use when fine-tuning 7B-70B models on limited GPU memory, when running QLoRA on a single 24GB GPU, when choosing LoRA rank and alpha, when merging or swapping adapters on one base model, or...

Hardware-agnostic quantum ML framework with automatic differentiation. Use when training quantum circuits via gradients, building hybrid quantum-classical models, or needing device portability across IBM/Google/Rigetti/IonQ. Best for variational algorithms (VQE, QAOA), quantum neural networks, and integration with PyTorch or JAX. For hardware-specific optimizations use qiskit (IBM) or cirq (Google); for open quantum systems use qutip.

Open-source AI observability platform for LLM tracing, evaluation, and monitoring. Use when debugging LLM applications with detailed traces, running evaluations on datasets, or monitoring production AI systems with real-time insights.

Build with and use Pi, the minimal terminal coding harness. Use for installing Pi, configuring providers/models/settings/environment variables, creating Pi skills/extensions/packages/themes/prompt templates, embedding Pi through the SDK, integrating over RPC or JSON event streams, parsing sessions, running local models through the llama.cpp router, developing custom Pi providers and TUI components, or using ecosystem packages such as pi-subagents (delegation/orchestration), pi-mcp-adapter (MC...

Guides use of Pinecone, a managed serverless vector database, through its Python client and the LangChain and LlamaIndex integrations. Covers creating indexes, upserting and querying vectors, metadata filtering, namespaces, hybrid dense and sparse search, index management, and deleting vectors. Use when building a production RAG system on a hosted vector store, adding semantic search or recommendations without running infrastructure, isolating per-user or per-tenant data with namespaces, comb...

Pharmacokinetic and pharmacodynamic modelling and simulation - non-compartmental analysis, compartmental and population PK, PK/PD and exposure-response, TMDD, PBPK orientation, bioequivalence, allometric scaling and first-in-human dose, drug interaction prediction, and Bayesian therapeutic drug monitoring. Use when analysing concentration-time data, deriving exposure metrics, fitting PK or PD models, or evaluating dosing regimens. Triggers include "pharmacokinetics", "pharmacodynamics", "PK/P...

Prepare manuscripts for PLOS journals (PLOS ONE, PLOS Biology, PLOS Computational Biology, PLOS Genetics, PLOS Medicine, PLOS Pathogens, PLOS Neglected Tropical Diseases, PLOS Global Public Health and others), covering structure, abstract and author summary, Vancouver-style references, the mandatory data availability policy, ethics and financial disclosure statements, figure requirements (PACE), the PLOS LaTeX template, reporting guidelines and PLOS ONE's publication criteria. Use when target...

Python library polars-bio for genomic interval operations and bioinformatics file I/O on Polars DataFrames, built on Arrow and DataFusion. Covers overlap, nearest, merge, cluster, coverage, complement, subtract, count_overlaps, per-base pileup depth, and read/scan/write of BED, VCF, BAM, CRAM, SAM, GFF/GTF, FASTA, FASTQ, plus SQL queries over those files. Use when intersecting or merging genomic intervals in Polars. Use when reading or streaming large BED, VCF, or BAM files, including from S3...

High-performance DataFrame library for Python ETL, analytics, and pandas migration. Use for expression-based data manipulation with lazy query optimization, parallel execution, streaming out-of-core processing, Arrow interoperability, and optional GPU execution.

Create and audit editable scientific posters in macro-free PowerPoint (.pptx) from author-approved local content and assets. Use when the requested deliverable is a PowerPoint research/conference poster and exact physical, printer, accessibility, provenance, and package-security checks are required.

Generates conference presentation slides (Beamer LaTeX PDF and editable PPTX) from a compiled paper with speaker notes and talk script. Use when preparing oral talks, spotlight presentations, or invited talks for ML and systems conferences.

Classifies text with Meta's Prompt Guard, an 86M-parameter model loaded from HuggingFace, into BENIGN, INJECTION or JAILBREAK labels to detect prompt injections and jailbreak attempts in LLM applications. Covers user input filtering, third-party data and RAG document filtering, batch processing, threshold tuning, and sliding-window handling of texts over 512 tokens. Use when screening user prompts for jailbreaks before they reach an LLM. Use when filtering API responses or retrieved RAG docum...

Reads, validates, and exports protocols.io data using the documented REST v3/v4 endpoints and the official MCP endpoint, and builds non-executing mutation plans. The bundled client makes bounded GET requests to official hosts only with --execute, and also validates saved protocol JSON offline for step order, version, DOI, and attribution metadata. Use when fetching a protocol, its steps, materials, or PDF from protocols.io by exact version. Use when validating a saved protocol snapshot for pr...

Version-aware guidance for PufferLib reinforcement-learning environments, vectorization, policies, PuffeRL training, evaluation, and safe checkpoint review. Use when adapting Gymnasium/PettingZoo environments to published PufferLib 3.0.0 or working with the redesigned native 4.0 source line.

Runs differential expression analysis on bulk RNA-seq count data with PyDESeq2, the Python port of DESeq2. Covers formulaic single- and multi-factor designs, contrasts, Wald tests, Benjamini-Hochberg FDR correction, optional apeGLM LFC shrinkage, pandas and AnnData (H5AD) integration, CSV export, volcano and MA plots, and a command-line script. Use when comparing gene expression between conditions such as treated vs control, adjusting for batch or covariates, porting an R DESeq2 workflow to P...

Reads, inspects, writes, and transforms local DICOM files with pydicom 3.x (dcmread, dcmwrite, pydicom.pixels), including metadata, transfer syntaxes, compressed pixel data plugins, frame decoding, private elements, DICOM JSON, and bounded pseudonymization review using bundled helper scripts. Use when extracting aggregate metadata from DICOM datasets without printing PHI, checking which transfer syntaxes and codec plugins a deployment needs, planning frame or memory limits before decoding pix...

Builds clinical deep-learning pipelines with PyHealth using its Dataset → Task → Model → Trainer → Metrics pattern. Covers loading MIMIC-III/IV, eICU, OMOP, SleepEDF, ChestXray14 and EHRShot data, defining prediction tasks (mortality, readmission, length of stay, drug recommendation, sleep staging, ICD coding, EEG events), models such as Transformer, RETAIN, GAMENet, SafeDrug and StageNet, training with Trainer, and ICD/ATC/NDC/RxNorm code lookup and cross-mapping. Use when building a clinica...

Develop and review PyLabRobot lab-automation resources, liquid-handling plans, offline simulations, and supported-device integrations. Use for PyLabRobot protocols or API questions; keep physical execution behind an explicit operator safety gate.

Analyzes, validates, converts, and transforms crystal structures and molecules with pymatgen. It covers CIF/POSCAR/XYZ/JSON conversion, symmetry-tolerance sweeps, local phase diagrams from computed entries, VASP and Q-Chem I/O, band structure and DOS parsing, and bounded Materials Project (mp-api) queries. Use when validating a CIF or checking disorder and oxidation states. Use when assigning space groups and testing symprec sensitivity. Use when converting structure files and checking for re...

Builds, fits, checks, and compares Bayesian models in Python with PyMC and ArviZ. Covers hierarchical (multilevel) models, NUTS MCMC sampling, variational inference (ADVI), prior and posterior predictive checks, convergence diagnostics (R-hat, ESS, divergences), and LOO/WAIC model comparison. Use when writing a PyMC model for regression, count, or binary data. Use when fitting a hierarchical model with partial pooling. Use when diagnosing divergences, low ESS, or high R-hat. Use when comparin...

Solves single- and multi-objective optimization problems in Python with pymoo, using NSGA-II, NSGA-III, MOEA/D, SPEA2, RVEA, GA, DE and PSO. Covers custom problems (Problem, ElementwiseProblem, FunctionalProblem), constraint handling, mixed-variable problems, ZDT/DTLZ/WFG benchmarks, genetic operators, parallel evaluation, Pareto front visualization and multi-criteria decision making. Use when finding Pareto-optimal trade-offs between conflicting objectives. Use when defining a constrained or...

Complete mass spectrometry analysis platform. Use for proteomics and metabolomics workflows—feature detection, peptide/protein identification, label-free and isobaric quantification, adduct/accurate-mass annotation, and complex LC-MS/MS pipelines. Supports extensive file formats and algorithms. For simple spectral comparison and small-molecule library matching use matchms.

Python/HTSlib workflows for genomic files. Use when reading, querying, filtering, or writing SAM/BAM/CRAM, VCF/BCF, FASTA/FASTQ, or tabix data with pysam, including pileup, coverage, indexing, and CRAM references.

Uses the PyTDC package (import tdc, Therapeutics Data Commons) to discover therapeutic ML tasks from tdc.metadata, plan and load approved datasets, apply task-aware splits (random, scaffold, cold_split, combination, time), run evaluator metrics, evaluate benchmark groups such as admet_group, and run bounded molecular-oracle scoring. Use when selecting a TDC task or dataset, planning a download-free split, scoring predictions with TDC evaluators, running a benchmark group evaluation, or checki...