Claude Skills by KalarisLabs

Observe the user's screen via screenpipe, detect repeated research workflows, match them against existing research-agent-skills, and draft new skills (or…

Estimates intracellular metabolic fluxes from steady-state carbon-13 isotope-tracing measurements using validated atom maps, mfapy isotope simulation, constrained multistart fitting, and flux-profile diagnostics. Use for 13C-MFA, carbon tracing, mass isotopomer distributions (MDVs/MIDs), positional isotopomers, parallel tracer experiments, and determining whether labeling data constrain a pathway flux. Distinguishes measured-label inference from COBRA flux balance analysis and flags experimen...

Write and sharpen research paper titles, abstracts (structured and unstructured), keywords, highlights, significance statements, graphical-abstract text and lay summaries. Use when drafting or revising an abstract to a word limit, turning results into a one-sentence contribution, choosing between candidate titles, writing Cell/Elsevier highlights, a PNAS significance statement or a plain-language summary, or optimizing discoverability (keywords, search terms).

Generates publication-quality figures for ML papers from research context. Given a paper section or description, extracts system components and relationships to generate architecture diagrams via Gemini. Given experiment results or data, auto-selects chart type and generates data-driven figures via matplotlib/seaborn. Use when creating any figure for a conference paper.

Format ACM conference papers and journal articles with the acmart LaTeX class (sigconf, sigplan, acmsmall, acmlarge, acmtog, manuscript/review/anonymous modes) or the ACM Word template, covering CCS concepts, keywords, ACM Reference Format, rights management and copyright blocks, anonymization for double-blind review, accessibility (alt text), the TAPS production workflow and common acmart errors. Use when writing for CHI, SIGGRAPH, KDD, SIGMOD, CCS, FAccT, WWW, SIGIR, CSCW, PLDI or any ACM v...

How to use the Adaptyv Bio Foundry API and Python SDK for protein experiment design, submission, and results retrieval. Use this skill whenever the user mentions Adaptyv, Foundry API, protein binding assays, protein screening experiments, BLI/SPR assays, thermostability assays, or wants to submit protein sequences for experimental characterization. Also trigger when code imports `adaptyv`, `adaptyv_sdk`, or `FoundryClient`, or references `foundry-api-public.adaptyvbio.com`.

This skill should be used for time series machine learning tasks including classification, regression, clustering, forecasting, anomaly detection, segmentation, and similarity search. Use when working with temporal data, sequential patterns, or time-indexed observations requiring specialized algorithms beyond standard ML approaches. Particularly suited for univariate and multivariate time series analysis with scikit-learn compatible APIs.

Look up precomputed AlphaGenome Atlas effects for any GRCh38 single-nucleotide variant (AVI score with Phred and 18 SHAP feature attributions, plus raw and quantile scores for RNA-seq, DNase, ATAC, ChIP-TF, ChIP-histone, CAGE, PRO-cap, splicing, polyadenylation and contact-map tracks), score variants or scan windows on demand with the AlphaGenome model for human and mouse (variant scoring, in silico mutagenesis, REF-versus-ALT track prediction), and build Atlas website deep links. Use when th...

Plans and evaluates analytical method validation, verification, and transfer using Python scripts (plan_validation, check_response, check_accuracy_precision, check_detection_limits, check_bioanalytical_run, compare_methods) under ICH Q2(R2)/Q14, ICH M10, USP 1220/1225/1226, CLSI EP, or ISO/IEC 17025. Covers protocols, linearity, accuracy and precision, DL/QL, M10 run checks, TOST equivalence, Deming and Passing-Bablok. Use when designing a validation protocol with pre-stated acceptance criter...

Data structure for annotated matrices in single-cell analysis. Use when working with .h5ad files or integrating with the scverse ecosystem. This is the data format skill—for analysis workflows use scanpy; for probabilistic models use scvi-tools; for population-scale queries use cellxgene-census.

Format papers, theses and references in APA Style 7th edition for psychology, education, social sciences, nursing and business, covering student vs professional papers, title page, abstract and keywords, heading levels, in-text citations, reference list entries (journal articles, books, chapters, datasets, software, webpages, AI tools), tables and figures, bias-free language, and APA via LaTeX (apa7 class + biblatex-apa), Word or Pandoc/CSL. Use when a user needs APA format, APA citations or ...

Compiles any research input — PDF papers, GitHub repositories, experiment logs, code directories, or raw notes — into a complete Agent-Native Research Artifact (ARA) with cognitive layer (claims, concepts, heuristics), physical layer (configs, code stubs), exploration graph, and grounded evidence. Use when ingesting a paper or codebase into a structured, machine-executable knowledge package, building an ARA from scratch, or converting research outputs into a falsifiable, agent-traversable form.

Records research provenance at the end of a coding or research session by scanning the conversation and writing decisions, experiments, dead ends, pivots, claims, and heuristics into the ara/ directory (exploration_tree.yaml, claims.md, heuristics.md, observations.yaml, session records), each tagged user, ai-suggested, ai-executed, or user-revised. Use when a task is finished and you want a session epilogue. Use when you need an auditable trace of how a project evolved. Use when decisions and...

Performs ARA Seal Level 2 semantic epistemic review of an Agent-Native Research Artifact directory, reading PAPER.md, logic/claims.md, logic/experiments.md, and trace/exploration_tree.yaml. Scores six dimensions (evidence relevance, falsifiability, scope calibration, argument coherence, exploration integrity, methodological rigor) from 1 to 5 and writes a severity-ranked level2_report.json with a Strong Accept to Reject grade. Use when Level 1 structural validation has passed and an ARA needs...

Autonomously improve a real artifact (code, training recipe, agent harness, data pipeline, prompt) against an objective and an evaluator, using Hypothesis Tree Refinement (HTR) from the Arbor paper. Use this whenever someone wants to iteratively optimize something over many experiments without overfitting — e.g. "get my model's eval score up", "improve this agent/harness", "tune this pipeline", "beat the baseline on this benchmark", "run a search over approaches and keep the best", "do an MLE...

Infer gene regulatory networks (GRNs) from gene expression data using scalable algorithms (GRNBoost2, GENIE3). Use when analyzing transcriptomics data (bulk RNA-seq, single-cell RNA-seq) to identify transcription factor-target gene relationships and regulatory interactions. Supports distributed computation for large-scale datasets.

Prepare and post preprints to arXiv without processing failures or leaks, covering TeX source packaging (.bbl, figures, case-sensitive paths), stripping private comments, choosing categories and license, endorsement, metadata (title, abstract, comments field), versioning and replacements, and linking the journal DOI later. Use when posting a paper to arXiv, when arXiv's TeX compilation fails, before uploading source, or when updating a preprint after acceptance. Includes a zero-dependency pre...

Core Python library for astronomy and astrophysics workflows that need Astropy APIs, including units/quantities, coordinates, FITS I/O, tables, time systems, WCS, and cosmology. Use when implementing or debugging astronomical data analysis code with Astropy.

PyTorch library for audio generation including text-to-music (MusicGen) and text-to-sound (AudioGen). Use when you need to generate music from text descriptions, create sound effects, or perform melody-conditioned music generation.

Autonomous AI agent platform for building and deploying continuous agents. Use when creating visual workflow agents, deploying persistent autonomous agents, or building complex multi-step AI automation systems.

Orchestrates end-to-end autonomous AI research projects using a two-loop architecture. The inner loop runs rapid experiment iterations with clear optimization targets. The outer loop synthesizes results, identifies patterns, and steers research direction. Routes to domain-specific skills for execution, supports continuous agent operation via Claude Code /loop and OpenClaw heartbeat, and produces research presentations and papers. Use when starting a research project, running autonomous experi...

Observe the user's screen via screenpipe, detect repeated research workflows, match them against existing research-agent-skills, and draft new skills (or composition recipes that chain existing ones) for the patterns not yet covered. Use when the user asks to analyze their recent work and propose skills based on what they actually do. Requires the screenpipe daemon (https://github.com/screenpipe/screenpipe) running locally on port 3030 — the skill has no other data source and will refuse to r...

Activation-aware weight quantization for 4-bit LLM compression with 3x speedup and minimal accuracy loss. Use when deploying large models (7B-70B) on limited GPU memory, when you need faster inference than GPTQ with better accuracy preservation, or for instruction-tuned and multimodal models. MLSys 2024 Best Paper Award winner.

Provides guidance for fine-tuning large language models with Axolotl, covering YAML training configs, LoRA and QLoRA, preference training with DPO, KTO, ORPO and GRPO, multimodal models, FSDP and multi-GPU setups, sequence (context) parallelism, NCCL bandwidth tests, dataset formats, compressed model saving for vLLM and llmcompressor, and custom integrations. Use when writing or debugging an Axolotl YAML config, choosing a dataset format for a fine-tuning run, setting up FSDP or context_paral...

Benchling Python SDK and REST API integration for registry entities, inventory, ELN entries, workflows, Benchling Apps, and Data Warehouse queries. Use when automating lab data with benchling-sdk or the v2 API.

Search scientific papers and retrieve structured experimental data extracted from full-text studies via the BGPT MCP server. Returns 25+ fields per paper including methods, results, sample sizes, quality scores, and conclusions. Use for literature reviews, evidence synthesis, and finding experimental details not available in abstracts alone.

Clean, deduplicate and validate BibTeX/BibLaTeX bibliographies before submission. Use when a .bib file has duplicate keys or works, missing fields, broken DOIs, lost acronym capitalization (e.g. "bert" instead of "BERT"), inconsistent page dashes, arXiv preprints that now have published versions, or when LaTeX/biber emits bibliography warnings. Includes a zero-dependency linter and normalizer.

Organizes, queries, validates, and converts neuroscience and biomedical datasets using the Brain Imaging Data Structure (BIDS) standard, covering MRI, PET, EEG, MEG, iEEG, EMG, NIRS, microscopy, motion capture, and behavioral data. Covers PyBIDS (BIDSLayout), the bids-validator, HeuDiConv, dcm2bids, BIDScoin, JSON sidecars, dataset_description.json, events.tsv, participants.tsv, .bidsignore, and derivatives. Use when arranging raw data into BIDS directories and filenames. Use when converting ...

Provides Biopython (Bio.Seq, Bio.SeqIO, Bio.Align, Bio.Entrez, Bio.Blast, Bio.PDB, Bio.Phylo, Bio.motifs, Bio.SeqUtils, Bio.Restriction) for sequence handling, file parsing, NCBI access, BLAST, structures, and phylogenetic trees in Python. Reads, writes, and converts FASTA, GenBank, FASTQ, PDB, mmCIF, Newick, and NEXUS files. Use when manipulating or translating DNA, RNA, or protein sequences, converting sequence file formats, fetching records from NCBI via Entrez, running or parsing BLAST se...

This skill provides comprehensive documentation organized by functionality area. When working on a task, consult the relevant reference documentation: **Reference:** `references/sequence_io.md` Use for: - Creating and manipulating biological sequences - Reading and writing sequence files (FASTA, GenBank, FASTQ, etc.) - Converting between file formats - Extracting sequences from large files - Sequence translation, transcription, and reverse complement - Working with SeqRecord objects **Quick e...

Unified Python interface to 40+ bioinformatics services. Use when querying multiple databases (UniProt, KEGG, ChEMBL, Reactome) in a single workflow with consistent API. Best for cross-database analysis, ID mapping across services. For quick single-database lookups use gget; for sequence/file manipulation use biopython.

Explains how to use Salesforce BLIP-2 (Q-Former bridging a frozen image encoder and an LLM such as OPT or FlanT5) through HuggingFace Transformers and LAVIS for image captioning, visual question answering, image-text matching, and feature extraction. Use when generating captions for images, building a VQA system, doing zero-shot image-text understanding without task-specific training, matching or retrieving images against text, or fitting a BLIP-2 model into limited GPU memory with INT8/INT4 ...

Guides researchers through structured ideation frameworks to discover high-impact research directions. Use when exploring new problem spaces, pivoting between projects, or seeking novel angles on existing work.

End-to-end bulk RNA-seq orchestrator — takes raw FASTQ reads through QC and trimming (FastQC, fastp/Trim Galore), alignment and quantification (STAR, Salmon, featureCounts), assembles a gene-level counts matrix, then hands off to differential expression (pydeseq2), pathway/GSEA enrichment (pathway-enrichment), and publication figures (scientific-visualization). Use whenever the user has bulk RNA-seq reads or quant output and wants a complete, reproducible differential-expression workflow — e....

Prepare manuscripts for Cell Press journals (Cell, Molecular Cell, Neuron, Immunity, Cell Reports, Cell Systems, iScience, Cell Metabolism, Current Biology and others), covering Summary, Highlights, eTOC blurb and graphical abstract, STAR Methods with the Key Resources Table, resource availability (lead contact, materials, data and code), figure and statistics requirements, and Cell Press formatting at submission vs revision. Use when targeting a Cell Press journal, writing highlights or a gr...

Query the CZ CELLxGENE Census programmatically for versioned public single-cell and spatial transcriptomics data. Use when you need population-scale cell metadata, gene expression slices, Census summary counts, source H5AD URIs/downloads, embeddings, spatial Census data, or reference atlas comparisons across organisms, tissues, diseases, assays, and cell types. For analyzing your own local single-cell data use scanpy, anndata, or scvi-tools.

Open-source embedding database for AI applications. Store embeddings and metadata, perform vector and full-text search, filter by metadata. Simple 4-function API. Scales from notebooks to production clusters. Use for semantic search, RAG applications, or document retrieval. Best for local development and open-source projects.

Google quantum computing framework. Use when targeting Google Quantum AI hardware, designing noise-aware circuits, or running quantum characterization experiments. Best for Google hardware, noise modeling, and low-level circuit design. For IBM hardware use qiskit; for quantum ML with autodiff use pennylane; for physics simulations use qutip.

Searches OpenAlex, PubMed, and Google Scholar, extracts metadata from DOIs, PMIDs, PMCIDs, arXiv IDs, and URLs via CrossRef, PubMed, and arXiv, then formats, deduplicates, and validates BibTeX files using bundled Python scripts (search_openalex.py, extract_metadata.py, format_bibtex.py, validate_citations.py, doi_to_bibtex.py). Use when converting DOIs or PMIDs to BibTeX, finding papers on a topic, filling missing volume, pages, or DOI fields, cleaning or merging .bib files with duplicate ent...

Verify that every reference in a manuscript really exists and matches its metadata, catching hallucinated, corrupted or mismatched citations before submission. Use when checking a .bib file or reference list, after an AI assistant drafted citations, when a DOI may point to the wrong paper, when adding missing DOIs, or before camera-ready. Queries Crossref, OpenAlex and arXiv; zero dependencies.

Prepare and validate research-only clinical decision-support evaluation, evidence-profile, cohort, survival, biomarker/model, privacy, and governance artifacts. Use for aggregate or synthetic research documentation and traceability—not patient care or live clinical operation.

Generates fail-closed draft JSON templates and runs local deterministic structure and consistency checks for clinical reports: CARE case reports, radiology, pathology and lab scaffolds, CONSORT 2025, SPIRIT 2025, ICH E3 CSRs, aggregate adverse-event tables, provenance manifests, terminology schemas, and de-identification process checklists. Use when drafting a case report for publication from a verified source-fact manifest. Use when checking a trial results manuscript, protocol, or CSR draft...

OpenAI's model connecting vision and language. Enables zero-shot image classification, image-text matching, and cross-modal retrieval. Trained on 400M image-text pairs. Use for image search, content moderation, or vision-language tasks without fine-tuning. Best for general-purpose image understanding.

Runs constraint-based metabolic modeling with COBRApy (Python, import cobra) on genome-scale models in SBML, JSON, YAML, or MATLAB format. Covers FBA, pFBA, geometric FBA, FVA, flux sampling, gene and reaction knockouts, production envelopes, growth media, gapfilling, and building models. Use when loading or exporting a genome-scale metabolic model. Use when predicting growth or flux distributions with FBA or FVA. Use when screening gene or reaction knockouts. Use when tuning growth media or ...

Run a multi-perspective Mind Council deliberation on any question, decision, or creative challenge. Use this skill whenever the user wants diverse viewpoints, needs help making a tough decision, asks for a council/panel/board discussion, wants to explore a problem from multiple angles, requests devil's advocate analysis, or says things like "what would different experts think about this", "help me think through this from all sides", "council mode", "mind council", or "deliberate on this". Als...

Anthropic's method for training harmless AI through self-improvement. Two-phase approach - supervised learning with self-critique/revision, then RLAIF (RL from AI Feedback). Use for safety alignment, reducing harmful outputs without human labels. Powers Claude's safety system.

Write journal submission cover letters, presubmission inquiries, transfer requests, and reviewer suggestion or exclusion lists that help a manuscript get past editorial triage. Use when submitting a paper to a journal, pitching a manuscript to an editor (presubmission enquiry), transferring after rejection, explaining a resubmission or appeal, or preparing the editor-facing parts of a submission such as the significance pitch, suggested reviewers and conflicts. Not for job or fellowship appli...

Applies cognitive science frameworks for creative thinking to CS and AI research ideation. Use when seeking genuinely novel research directions by leveraging combinatorial creativity, analogical reasoning, constraint manipulation, and other empirically grounded creative strategies.

Multi-agent orchestration framework for autonomous AI collaboration. Use when building teams of specialized agents working together on complex tasks, when you need role-based agent collaboration with memory, or for production workflows requiring sequential/hierarchical execution. Built without LangChain dependencies for lean, fast execution.

Distributed computing for larger-than-RAM pandas/NumPy workflows. Use when you need to scale existing pandas/NumPy code beyond memory or across clusters. Best for parallel file processing, distributed ML, integration with existing pandas code. For out-of-core analytics on single machine use vaex; for in-memory speed use polars.