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---
name: risk-of-bias-assessment
description: Assess methodological bias using RoB2, PROBAST, or QUADAS-2 validated tools
execution: subagent
prompt: ./prompt.md
input: study_metadata, study_design
used-by: meta-analysis
---
# Risk of Bias Assessment SOP
Conduct structured risk-of-bias assessment for individual studies using the appropriate validated tool (RoB 2.0, ROBINS-I, QUADAS-2, PROBAST, or Newcastle-Ottawa Scale).
## When to Use
- During quality assessment of each included study
- When deciding sensitivity analysis groupings
- When assessing GRADE certainty (risk of bias domain)
## Input
- `study_metadata`: Study characteristics, methods description, and results
- `study_design`: The study design (RCT, non-randomized, diagnostic, prediction model, observational)
## Output
Domain-level risk-of-bias judgments with supporting rationale for each signaling question.
