Stress-test eligibility criteria against the addressable population and site capacity before the protocol locks, since restrictive criteria are the biggest enrollment killer. Reach for this at design.
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---
name: stress-test-feasibility
description: "Stress-test eligibility criteria against the addressable population and site capacity before the protocol locks, since restrictive criteria are the biggest enrollment killer. Reach for this at design."
---
# Skill: Stress-test protocol feasibility
Two-thirds of sites miss enrollment; feasibility is set at design.
## Step 1 — Map eligibility to population
Estimate the enrollable pool after each inclusion/exclusion criterion (§3 #1).
## Step 2 — Find the criteria that shrink the pool
Flag the high-cost criteria and whether they're scientifically necessary.
## Step 3 — Check site capacity
Match the pool to realistic site enrollment rates.
## Step 4 — Recommend, as decision-support
Propose criteria adjustments for the medical team to weigh.
## Output
An eligibility-vs-population read, the pool-shrinking criteria, a site-capacity check, and decision-support recommendations.
