Full Protein Analysis

---
name: full_protein_analysis
description: 'Full Protein Characterization - Complete protein characterization: validate
  sequence, compute all properties, predict structure, and analyze pockets. Use this
  skill for protein biochemistry tasks involving is valid protein sequence analyze
  protein ComputeProtPara pred protein structure esmfold run fpocket. Combines 5 tools
  from 4 SCP server(s).'
i18n:
  zh:
    description: 全面蛋白质分析：序列验证、性质。
---

# Full Protein Characterization

**Discipline**: Protein Biochemistry | **Tools Used**: 5 | **Servers**: 4

## Description

Complete protein characterization: validate sequence, compute all properties, predict structure, and analyze pockets.

## Tools Used

- **`is_valid_protein_sequence`** from `server-2` (streamable-http) - `https://scp.intern-ai.org.cn/api/v1/mcp/2/DrugSDA-Tool`
- **`analyze_protein`** from `server-17` (streamable-http) - `https://scp.intern-ai.org.cn/api/v1/mcp/17/BioInfo-Tools`
- **`ComputeProtPara`** from `server-29` (sse) - `https://scp.intern-ai.org.cn/api/v1/mcp/29/SciToolAgent-Bio`
- **`pred_protein_structure_esmfold`** from `server-3` (streamable-http) - `https://scp.intern-ai.org.cn/api/v1/mcp/3/DrugSDA-Model`
- **`run_fpocket`** from `server-3` (streamable-http) - `https://scp.intern-ai.org.cn/api/v1/mcp/3/DrugSDA-Model`

## Workflow

1. Validate sequence
2. Analyze protein features
3. Compute protein parameters
4. Predict 3D structure
5. Predict binding pockets

## Test Case

### Input
```json
{
    "sequence": "MKTIIALSYIFCLVFAGKRDEFPSTWYV"
}
```

### Expected Steps
1. Validate sequence
2. Analyze protein features
3. Compute protein parameters
4. Predict 3D structure
5. Predict binding pockets

## Usage Example

> **Note:** Replace `<YOUR_SCP_HUB_API_KEY>` with your own SCP Hub API Key. You can obtain one from the [SCP Platform](https://scphub.intern-ai.org.cn).

```python
import asyncio
import json
from mcp import ClientSession
from mcp.client.streamable_http import streamablehttp_client
from mcp.client.sse import sse_client

SERVERS = {
    "server-2": "https://scp.intern-ai.org.cn/api/v1/mcp/2/DrugSDA-Tool",
    "server-17": "https://scp.intern-ai.org.cn/api/v1/mcp/17/BioInfo-Tools",
    "server-29": "https://scp.intern-ai.org.cn/api/v1/mcp/29/SciToolAgent-Bio",
    "server-3": "https://scp.intern-ai.org.cn/api/v1/mcp/3/DrugSDA-Model"
}

async def connect(url, transport_type):
    transport = streamablehttp_client(url=url, headers={"SCP-HUB-API-KEY": "<YOUR_SCP_HUB_API_KEY>"})
    read, write, _ = await transport.__aenter__()
    ctx = ClientSession(read, write)
    session = await ctx.__aenter__()
    await session.initialize()
    return session, ctx, transport

def parse(result):
    try:
        if hasattr(result, 'content') and result.content:
            c = result.content[0]
            if hasattr(c, 'text'):
                try: return json.loads(c.text)
                except: return c.text
        return str(result)
    except: return str(result)

async def main():
    # Connect to required servers
    sessions = {}
    sessions["server-2"], _, _ = await connect("https://scp.intern-ai.org.cn/api/v1/mcp/2/DrugSDA-Tool", "streamable-http")
    sessions["server-17"], _, _ = await connect("https://scp.intern-ai.org.cn/api/v1/mcp/17/BioInfo-Tools", "streamable-http")
    sessions["server-29"], _, _ = await connect("https://scp.intern-ai.org.cn/api/v1/mcp/29/SciToolAgent-Bio", "sse")
    sessions["server-3"], _, _ = await connect("https://scp.intern-ai.org.cn/api/v1/mcp/3/DrugSDA-Model", "streamable-http")

    # Execute workflow steps
    # Step 1: Validate sequence
    result_1 = await sessions["server-2"].call_tool("is_valid_protein_sequence", arguments={})
    data_1 = parse(result_1)
    print(f"Step 1 result: {json.dumps(data_1, indent=2, ensure_ascii=False)[:500]}")

    # Step 2: Analyze protein features
    result_2 = await sessions["server-17"].call_tool("analyze_protein", arguments={})
    data_2 = parse(result_2)
    print(f"Step 2 result: {json.dumps(data_2, indent=2, ensure_ascii=False)[:500]}")

    # Step 3: Compute protein parameters
    result_3 = await sessions["server-29"].call_tool("ComputeProtPara", arguments={})
    data_3 = parse(result_3)
    print(f"Step 3 result: {json.dumps(data_3, indent=2, ensure_ascii=False)[:500]}")

    # Step 4: Predict 3D structure
    result_4 = await sessions["server-3"].call_tool("pred_protein_structure_esmfold", arguments={})
    data_4 = parse(result_4)
    print(f"Step 4 result: {json.dumps(data_4, indent=2, ensure_ascii=False)[:500]}")

    # Step 5: Predict binding pockets
    result_5 = await sessions["server-3"].call_tool("run_fpocket", arguments={})
    data_5 = parse(result_5)
    print(f"Step 5 result: {json.dumps(data_5, indent=2, ensure_ascii=False)[:500]}")

    # Cleanup
    print("Workflow complete!")

if __name__ == "__main__":
    asyncio.run(main())
```