This skill recommends checking triglyceride levels before and after starting a bile acid sequestrant in patients with elevated triglycerides (150-499 mg/dL). Clinical triggers include: triglyceride level 150-499 mg/dL, consideration of bile acid sequestrant for hypertriglyceridemia, and monitoring of therapeutic response to bile acid sequestrant.
Installs into .claude/skills of the current project.
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---
name: endo-tg-check-bile-acid-sequestrant
description: This skill recommends checking triglyceride levels before and after starting a bile acid sequestrant in patients with elevated triglycerides (150-499 mg/dL). Clinical triggers include: triglyceride level 150-499 mg/dL, consideration of bile acid sequestrant for hypertriglyceridemia, and monitoring of therapeutic response to bile acid sequestrant.
---
# Triglyceride monitoring before and after bile acid sequestrant initiation
## STEP 1 — Gather Information
Collect current fasting triglyceride level and assess clinical indication for bile acid sequestrant (e.g., for hypertriglyceridemia or adjunct glycemic control in diabetes).
## STEP 2 — Rule In / Rule Out
Rule in if triglyceride level is between 150 mg/dL and 499 mg/dL; rule out if triglyceride level is <150 mg/dL or ≥500 mg/dL.
## STEP 3 — Classify or Stratify
Classify as appropriate for bile acid sequestrant initiation with planned triglyceride monitoring if no contraindications (triglyceride level <500 mg/dL, already confirmed in step 2).
## STEP 4 — Decide
Initiate bile acid sequestrant and schedule triglyceride measurement before initiation and 4-6 weeks after initiation to assess response and safety.
## Clinical Guardrails / Mimics / Pitfalls
Do not initiate bile acid sequestrant if triglyceride level is ≥500 mg/dL due to risk of exacerbating hypertriglyceridemia and pancreatitis. Monitor for triglyceride elevation after initiation; if triglyceride rises to ≥500 mg/dL, discontinue and evaluate for alternative therapy.
## Concrete Clinical Example
A 58-year-old patient with type 2 diabetes and fasting triglyceride of 280 mg/dL is prescribed colesevelam for glycemic adjunct. Pre-treatment triglyceride is 280 mg/dL. At 6-week follow-up, triglyceride is 310 mg/dL (increased but <500 mg/dL); therapy continues with lipid monitoring every 3 months.
**Source:** Lipid Management in Patients with Endocrine Disorders: An Endocrine Society Clinical Practice Guideline, Endocrine Society, 2020, doi:10.1210/clinem/dgaa674
> **TODO:** consider adding scripts/calc.py for the endo-tg-check-bile-acid-sequestrant calculator
