Recommends against routine 25(OH)D testing during pregnancy. Use when a clinician considers ordering 25(OH)D tests for pregnant patients lacking established indications such as hypocalcemia or malabsorption.
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---
name: endo-against-25ohd-test-pregnancy
description: Recommends against routine 25(OH)D testing during pregnancy. Use when a clinician considers ordering 25(OH)D tests for pregnant patients lacking established indications such as hypocalcemia or malabsorption.
---
# Against routine 25(OH)D testing during pregnancy
## STEP 1 — Gather Information
Confirm pregnancy and gestational age; assess for established indications for 25(OH)D testing (e.g., hypocalcemia, malabsorption syndromes, chronic kidney disease, osteoporosis treatment, prior bariatric surgery) and review symptoms suggestive of vitamin D deficiency.
## STEP 2 — Rule In / Rule Out
If an established indication is present, proceed to 25(OH)D testing; if no established indication is identified, rule out routine testing.
## STEP 3 — Classify or Stratify
Classify patients without indications as “routine testing not indicated”; those with indications proceed to testing per clinical judgment.
## STEP 4 — Decide
For patients without indications, do not order routine 25(OH)D testing; consider empiric vitamin D supplementation per Recommendation 8 if desired, but do not base dosing on 25(OH)D levels.
## Clinical Guardrails / Mimics / Pitfalls
Do not use 25(OH)D results to guide vitamin D supplementation dosing in pregnancy; avoid testing low‑risk pregnant individuals solely for deficiency screening; recognize that empiric supplementation may be beneficial but testing adds cost and may exacerbate inequities; do not interpret 25(OH)D levels using non‑pregnancy‑specific thresholds.
## Concrete Clinical Example
A 30‑year‑old patient at 16 weeks gestation requests a vitamin D level after reading online; she has no history of hypocalcemia, bariatric surgery, chronic kidney disease, or other indications. Clinician advises against routine testing, discusses empiric vitamin D supplementation (e.g., 600–2000 IU daily) if she wishes, and documents that testing is not required.
**Source:** Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline, Endocrine Society, 2024, https://doi.org/10.1210/clinem/dgae290
