Research

Skill for curating microbiome-related pathophysiology in the dismech knowledge base. Use this skill when adding dysbiosis mechanisms, ecological concepts (Anna Karenina, keystone taxa, colonization resistance), SCFA/metabolite pathways, and linking microbial ecology to disease pathophysiology. Covers IBD, C. diff, obesity, and other microbiome-associated conditions.

Assess how much evidence AOP-Wiki actually carries for a Key Event Relationship before curating from it. Use when judging whether a KER, or a set of them, is backed by literature; when reading `completion_score`, `weight_of_evidence`, `empirical_support`, or `oecd_status` off a KER or its parent AOP; when deciding how much deep-research effort an AOP-derived causal edge will cost; or when auditing an existing dismech edge whose provenance traces to AOP-Wiki.

Skill for initiating new disorder YAML files in the dismech knowledge base. Use this skill when the user asks to create a new disorder entry. Also useful for enhancing existing entries.

Add, validate, repair, or review evidence references and exact-quote snippets in dismech KB YAML and deep-research reports. Use for PMID, DOI, NCT, ICTRP, or structured-source evidence; reference-cache generation; snippet failures; title snippets; bracket normalization; deep-research citation validation; Named Entity Confusion preflight; evidence_source classification; and final evidence checks before a PR.

Skill for creating a new mechanism module in kb/modules/ (a conserved pathological process that recurs across disorders). Use when the user asks to create/curate a module, add an Xogenesis (pathological-structure-formation) module, or factor a recurrent mechanism out of several disorders. Covers the module schema shape, the trigger→consequence node chain, the treatment target_mechanisms drug pattern, the Xogenesis open-ontology anchor convention, evidence discipline, validation, and registrat...

当需要定位个人或品牌的独特定位，以在竞争中脱颖而出时

当需要在信息过载和AI普及的环境中进行有效创作，以建立个人独特性时

当面临个人效率、习惯养成、情绪管理或健康等复杂个人系统问题时，用于通过结构化实验寻找有效解决方案

当需要系统性地规划个人或团队在数字时代的核心能力发展路径时

当需要解决个人成长、技能获取或生活优化中的具体问题，且现有单一方案效果不佳时

当需要寻找最适合个人或特定情境的有效方法，而非盲目套用通用建议时；或在尝试新方法后需要评估和优化时

当需要高效自学并内化一项新技能或方法论，而非仅仅获取知识时

当面对个人效率、习惯养成、健康管理等问题，需要寻找最适合自身的个性化解决方案时

当需要为自己或特定情境设计有效的行为习惯或工作流程时

当对新目标或领域感兴趣，但不确定何种具体行动适合自己、能持续时

当个人在生活、工作或成长中遇到持续性问题或陷入迷茫，需要寻找个性化解决方案时

当个人感到迷茫、缺乏方向感，或想从解决自身问题出发找到人生目标时

当遇到重复性、顽固的个人问题（如效率低下、习惯难以改变、健康问题、情绪问题），且标准解决方案无效时

当需要从个人经验、技能和兴趣中识别可产品化的知识或服务时

当面对个人成长、习惯养成或解决自身复杂挑战时

当需要将抽象的个人提升目标（如变健康、赚更多钱）转化为可积累和货币化的具体经验时

当寻找个人事业方向、创业点子或内容创作主题时

当个体希望找到能让自己全情投入、不再在意外界评价的内在驱动力或长期兴趣时

当个体感到迷茫，希望找到人生方向或使命，但不知从何开始时