Business & Operations

Expert-thinking profile for Protein Engineer (directed evolution / display selection / biophysical characterization / ML-guided design / developability): Reasons from sequence-structure-function relationships, evolutionary constraint, and multiparameter developability through display selection, ProteinMPNN/RFdiffusion and AlphaFold modeling, SPR/BLI kinetics, and SEC/DSF/CE-SDS characterization while treating aggregation, Tm loss, proteolysis, glycoform mismatch, and...

Expert-thinking profile for Propulsion Engineer (engine design / hot-fire test / combustion stability / rockets-airbreathing-EP / cycle analysis): Reasons from thrust, specific impulse, characteristic velocity c*, thrust coefficient Cf, and NPSH through NASA CEA, RPA and NPSS cycle models, hot-fire thrust stands, and ROCCID/bomb-test stability screening while treating nozzle separation, inducer cavitation, chugging/screech combustion instability, and scramjet...

Develop evidence-backed structural and architectural security hardening proposals from vulnerability disclosures, supplied findings, incident or assessment documents, source code, or a completed Codex Security scan. Use when a user asks for systemic improvements, alternatives beyond per-finding patches, before-and-after security architecture views, engineering tradeoff analysis, or an implementation-ready plan for a selected hardening option. Also use automatically after a Codex Security scan...

Create or refine promptfoo redteam setup configs: purpose, targets, plugins, strategies, frameworks, multi-input target inputs, policy text, grader guidance, contexts, and static-code-derived target/threat mapping. Use when preparing a red team scan plan from live probes, code evidence, or provider configs, or when generating adversarial test cases for QA. Do not use for basic provider wiring alone or for running/evaluating an already-generated redteam scan.

Prisma Compute deployment and hosting guide. Use whenever the user mentions Prisma Compute, `prisma.compute.ts`, `defineComputeConfig`, deploying or hosting a Prisma app, `@prisma/cli app deploy`, `compute:deploy`, `create-prisma --deploy`, `PRISMA_SERVICE_TOKEN`, Compute auth/workspaces, apps/deployments/build logs/domains, localhost vs `0.0.0.0`, deploy port binding, or framework deploy readiness for Hono, Elysia, Next.js, TanStack Start, Astro, Nuxt, Svelte, Nest, Turborepo, or custom/preb...

Precedent M&A transactions analysis with deal multiples and acquisition

Expert-thinking profile for Power Systems Engineer (power flow / protection coordination / DER hosting / stability & EMT / standards (NERC TPL, IEEE 1547, IEC 60909)): Reasons from per-unit impedances, symmetrical components, swing equations, and relay reach through PSS/E, OpenDSS, Aspen OneLiner, PSCAD, and NERC TPL/IEEE 1547/IEC 60909 criteria while treating loss of protection selectivity, DER-driven reverse power flow and voltage rise, CT saturation, and voltage collapse as...

Expert-thinking profile for Poultry Scientist (pen/house trials / nutrition & feed formulation / gut health & coccidiosis / hatchery & incubation / processing yield / poultry welfare): Reasons from flock-level feed-to-gain conversion, digestible amino acid balance, and thermal/respiratory/pathogen load through FCR/EPEF and HDEP/HOF metrics, pen-or-house mixed models, coccidiosis lesion scoring, hatchery break-out, and strain management guides while treating subclinical coccidiosis and necroti...

Expert-thinking profile for Pollution Control Engineer (design / engineering / regulatory compliance): Reasons from PTE, Title V Part 70, and NPDES limits through scrubber/baghouse/ESP/RTO selection, CEMS and stack-test demonstration, and parametric O&M (ΔP, pH, L/G) while treating synthetic-minor strategy, sulfite-blinded FGD, bag leaks, and WET/TIE toxicity as first-class failure modes.

Expert-thinking profile for Planetary Geologist (remote sensing / GIS / planetary surfaces (Mars, Moon)): Reasons from stratigraphy and landform genesis through ISIS/GDAL/JMARS/ArcGIS, CraterTools/CSFD Tools/CraterStats2 chronology, CRISM/M3/THEMIS spectroscopy with SPLib/RELAB, and PDS archives while treating secondaries, projection/datums, and production-function choice as first-class failure modes.

Use when planning Zoom integrations.

Expert-thinking profile for Pharmacovigilance Scientist (regulatory / drug safety surveillance (clinical & post-marketing)): Reasons from ICSR validity, MedDRA/SMQ coding, seriousness/expectedness/listedness, WHO-UMC causality, and PRR/ROR/IC/EBGM signal workflows through E2B(R3), EudraVigilance/FAERS/VigiBase, GVP Modules VI–IX, and PSUR/PBRER/RMP while treating duplicates, MLM scope, innocent-bystander confounding, and Weber/stimulated...

Expert-thinking profile for Petrologist (igneous/metamorphic petrology / petrography / EPMA-LA-ICP-MS microanalysis / thermodynamic modeling (Perple_X, THERMOCALC, MELTS)...): Reasons from Gibbs free energy minimization, the phase rule, and protolith-specific facies assemblages through petrography, EPMA/LA-ICP-MS microanalysis, pseudosections (Perple_X, THERMOCALC, MELTS), and classical thermobarometry while treating retrograde overprinting, serpentinization, propylitic alteration mimicking...

Expert-thinking profile for Petroleum / Reservoir Engineer (field development / dynamic subsurface (MBE, PTA, simulation, reserves)): Reasons from Darcy flow, Havlena–Odeh MBE, Fetkovich/VEH aquifers, Horner/derivative PTA, Buckley–Leverett/Welge floods, Eclipse/CMG/tNavigator history match, PRMS/SEC reserves (P90/P50/P10), and SPE11 CO₂ benchmarks; treats transient Arps b>1, negative-skin grid artifacts, and microseismic≠SRV as first-class failure...

Expert-thinking profile for Petrochemist (refinery process chemistry / crude assay / fuels & lubricants spec testing / catalyst performance / standards (ASTM D02, EN 228/590)): Reasons from boiling range, hydrocarbon class, sulfur/nitrogen speciation, and octane/cetane drivers through SimDist and PIONA/SARA group-type analysis, CFR- engine RON/MON and cetane testing, refinery LP models, and ASTM/EN spec methods, while treating light-ends loss, assay mismatch versus plant yields, catalyst...

Gene-set pathway enrichment analysis using Enrichr — queries KEGG, GO (BP/MF/CC), Reactome, WikiPathways, MSigDB, and Disease Ontology. Produces ranked pathway tables, interactive bubble charts, and a reproducible Markdown report.

ParaView scientific visualization for volume data and meshes. Use this skill when Claude needs to: (1) Visualize 3D volume data (CT, MRI, scientific simulations), (2) Create isosurfaces, slices, volume renderings, (3) Visualize vector fields with streamlines/glyphs, (4) Generate publication-quality screenshots, (5) Work with VTK, EXODUS, RAW, or other scientific data formats

Expert-thinking profile for Palliative Care Researcher (clinical trials / symptom science / patient-reported outcomes / health services / reporting (CONSORT-PRO, SPIRIT, PCORI)): Reasons from serious-illness trajectories, multidimensional symptom burden, goals-of-care concordance, and caregiver dyad outcomes through validated PROMs (ESAS-r, IPOS, FACIT-Pal), prespecified MCID responder analysis, mixed-effects and joint survival-QoL models, and CONSORT-PRO/SPIRIT/PCORI reporting while treating...

Operator toolkit for nf-core/pacsomatic matched tumor-normal workflows from BAM inputs. Use this skill when the user needs to validate run inputs, generate pacsomatic-compliant samplesheets, prepare reproducible Nextflow launch artifacts, run locally or submit to schedulers (LSF/Slurm/PBS/SGE), and triage execution failures. Triggers on requests to run pacsomatic, prepare launch commands/scripts, perform dry-run checks, or troubleshoot pipeline startup and scheduler submission errors.

Expert-thinking profile for Optimization Scientist (computational / mathematical optimization): Reasons from convexity class, KKT/complementarity, and LP/MIP relaxation gaps through interior-point and branch-and-cut (Gurobi, CPLEX, MOSEK, Ipopt) while treating loose big-M, IntegralityTol cheaters, IIS-hidden infeasibility, nonconvex KKT-as-global, and MIPGap-at-TimeLimit-as-optimal as first-class failure modes.

Expert-thinking profile for Ophthalmologist (clinical / retina, glaucoma & vision trials): Reasons from structure–function pairing (OCT RNFL/CST, HVF MD/VFI, ETDRS BCVA); manages glaucoma IOP targets and anti-VEGF treat-and-extend while treating field learning effect, OCT floor effect, and 15-letter regulatory margins as first- class failure modes.

Expert-thinking profile for Operations Researcher (optimization modeling / stochastic & robust programming / discrete-event simulation / VRP & scheduling / production solve ops (ERP/WMS/TMS)): Reasons from decision structure, integrality and convexity, and explicit uncertainty through LP/MIP solvers (Gurobi, CPLEX, OR-Tools CP-SAT), stochastic and Wasserstein-distributionally-robust formulations, and DES (SimPy, AnyLogic) benchmarked on Solomon/MIPLIB instances, while treating unit inconsiste...

Expert-thinking profile for Oncologist (clinical / multidisciplinary oncology): Stages with AJCC TNM and molecular prognostic groups, selects biomarker-matched therapy from NCCN guidelines, assesses response with RECIST 1.1/iRECIST, and interprets trial endpoints with calibrated clinical judgment.

Create, analyze, proofread, and modify Office documents (.docx, .xlsx, .pptx) using the officecli CLI tool. Use when the user wants to create, inspect, check formatting, find issues, add charts, or modify Office documents.