Claude Skills by luokai0

Build complex AI systems with declarative programming, optimize prompts automatically, create modular RAG systems and agents with DSPy - Stanford NLP's framework for systematic LM programming

Python library for accessing, analyzing, and extracting data from SEC EDGAR filings. Use when working with SEC filings, financial statements (income statement, balance sheet, cash flow), XBRL financial data, insider trading (Form 4), institutional holdings (13F), company financials, annual/quarterly reports (10-K, 10-Q), proxy statements (DEF 14A), 8-K current events, company screening by ticker/CIK/industry, multi-period financial analysis, or any SEC regulatory filings.

Convert documents and text to audio using ElevenLabs text-to-speech. Use this skill when the user wants to create a podcast, narrate a document, read aloud text, generate audio from a file, or convert text to speech.

Access European Nucleotide Archive via API/FTP. Retrieve DNA/RNA sequences, raw reads (FASTQ), genome assemblies by accession, for genomics and bioinformatics pipelines. Supports multiple formats.

Query Ensembl genome database REST API for 250+ species. Gene lookups, sequence retrieval, variant analysis, comparative genomics, orthologs, VEP predictions, for genomic research.

Use this agent when distributed system errors occur and need coordinated handling across multiple components, or when you need to implement comprehensive error recovery strategies with automated fa...

Comprehensive toolkit for protein language models including ESM3 (generative multimodal protein design across sequence, structure, and function) and ESM C (efficient protein embeddings and representations). Use this skill when working with protein sequences, structures, or function prediction; designing novel proteins; generating protein embeddings; performing inverse folding; or conducting protein engineering tasks. Supports both local model usage and cloud-based Forge API for scalable infer...

Phylogenetic tree toolkit (ETE). Tree manipulation (Newick/NHX), evolutionary event detection, orthology/paralogy, NCBI taxonomy, visualization (PDF/SVG), for phylogenomics.

Interact with EVM-compatible blockchains using Foundry's cast tool for querying balances, calling contracts, sending transactions, and blockchain exploration. Use when needing to interact with Ethereum Virtual Machine networks via command-line, including reading contract state, sending funds, executing contract functions, or inspecting blockchain data.

CRITICAL: Use for makepad-skills self-evolution and contribution. Triggers on: evolve, evolution, contribute, contribution, self-improve, self-improvement, add pattern, new pattern, capture learning, document solution, hooks, hook system, auto-trigger, skill routing, template, pattern template, shader template, troubleshooting template, 演进, 贡献, 自我改进, 添加模式, 记录学习, 文档化解决方案

Analyze existing repositories, maintain structure, setup guardrails and best practices

Perform comprehensive exploratory data analysis on scientific data files across 200+ file formats. This skill should be used when analyzing any scientific data file to understand its structure, content, quality, and characteristics. Automatically detects file type and generates detailed markdown reports with format-specific analysis, quality metrics, and downstream analysis recommendations. Covers chemistry, bioinformatics, microscopy, spectroscopy, proteomics, metabolomics, and general scien...

Facebook's library for efficient similarity search and clustering of dense vectors. Supports billions of vectors, GPU acceleration, and various index types (Flat, IVF, HNSW). Use for fast k-NN search, large-scale vector retrieval, or when you need pure similarity search without metadata. Best for high-performance applications.

Generate favicons from a source image

Query openFDA API for drugs, devices, adverse events, recalls, regulatory submissions (510k, PMA), substance identification (UNII), for FDA regulatory data analysis and safety research.

Generate a branded social media image announcing a new feature or update. Analyzes git history, auto-detects brand from codebase (Tailwind, CSS vars, design tokens), replicates UI elements, and captures via Playwright. Use when the user wants to create an announcement image, says 'feature image,' 'announcement graphic,' 'social image for feature,' or wants to visually announce a code change.

Firebase Firestore, Auth, Storage, real-time listeners, security rules

Optimizes transformer attention with Flash Attention for 2-4x speedup and 10-20x memory reduction. Use when training/running transformers with long sequences (>512 tokens), encountering GPU memory issues with attention, or need faster inference. Supports PyTorch native SDPA, flash-attn library, H100 FP8, and sliding window attention.

Parse FCS (Flow Cytometry Standard) files v2.0-3.1. Extract events as NumPy arrays, read metadata/channels, convert to CSV/DataFrame, for flow cytometry data preprocessing.

Framework for computational fluid dynamics simulations using Python. Use when running fluid dynamics simulations including Navier-Stokes equations (2D/3D), shallow water equations, stratified flows, or when analyzing turbulence, vortex dynamics, or geophysical flows. Provides pseudospectral methods with FFT, HPC support, and comprehensive output analysis.

Query FRED (Federal Reserve Economic Data) API for 800,000+ economic time series from 100+ sources. Access GDP, unemployment, inflation, interest rates, exchange rates, housing, and regional data. Use for macroeconomic analysis, financial research, policy studies, economic forecasting, and academic research requiring U.S. and international economic indicators.

Build a complete autonomous AI agent system at absolute zero cost. Full verified stack: Oracle Cloud Always Free VPS for 24/7 uptime, Gemini Flash free tier for AI, Groq for fast reasoning, Telegram as interface, Supabase for database, Netlify for web presence. No credit card required for any component.

Multi-agent orchestrator for Claude Code. Use when user mentions gastown, gas town, gt commands, bd commands, convoys, polecats, crew, rigs, slinging work, multi-agent coordination, beads, hooks, molecules, workflows, the witness, the mayor, the refinery, the deacon, dogs, escalation, or wants to run multiple AI agents on projects simultaneously. Handles installation, workspace setup, work tracking, agent lifecycle, crash recovery, and all gt/bd CLI operations.

Google Gemini CLI code review with Gemini 2.5 Pro, 1M token context, CI/CD integration

Query NCBI Gene via E-utilities/Datasets API. Search by symbol/ID, retrieve gene info (RefSeqs, GO, locations, phenotypes), batch lookups, for gene annotation and functional analysis.

Generate or edit images using AI models (FLUX, Nano Banana 2). Use for general-purpose image generation including photos, illustrations, artwork, visual assets, concept art, and any image that is not a technical diagram or schematic. For flowcharts, circuits, pathways, and technical diagrams, use the scientific-schematics skill instead.

This skill should be used when working with genomic interval data (BED files) for machine learning tasks. Use for training region embeddings (Region2Vec, BEDspace), single-cell ATAC-seq analysis (scEmbed), building consensus peaks (universes), or any ML-based analysis of genomic regions. Applies to BED file collections, scATAC-seq data, chromatin accessibility datasets, and region-based genomic feature learning.

Access NCBI GEO for gene expression/genomics data. Search/download microarray and RNA-seq datasets (GSE, GSM, GPL), retrieve SOFT/Matrix files, for transcriptomics and expression analysis.

Comprehensive geospatial science skill covering remote sensing, GIS, spatial analysis, machine learning for earth observation, and 30+ scientific domains. Supports satellite imagery processing (Sentinel, Landsat, MODIS, SAR, hyperspectral), vector and raster data operations, spatial statistics, point cloud processing, network analysis, cloud-native workflows (STAC, COG, Planetary Computer), and 8 programming languages (Python, R, Julia, JavaScript, C++, Java, Go, Rust) with 500+ code examples...

Python library for working with geospatial vector data including shapefiles, GeoJSON, and GeoPackage files. Use when working with geographic data for spatial analysis, geometric operations, coordinate transformations, spatial joins, overlay operations, choropleth mapping, or any task involving reading/writing/analyzing vector geographic data. Supports PostGIS databases, interactive maps, and integration with matplotlib/folium/cartopy. Use for tasks like buffer analysis, spatial joins between ...

This skill should be used at the start of any computationally intensive scientific task to detect and report available system resources (CPU cores, GPUs, memory, disk space). It creates a JSON file with resource information and strategic recommendations that inform computational approach decisions such as whether to use parallel processing (joblib, multiprocessing), out-of-core computing (Dask, Zarr), GPU acceleration (PyTorch, JAX), or memory-efficient strategies. Use this skill before runni...

Fast CLI/Python queries to 20+ bioinformatics databases. Use for quick lookups: gene info, BLAST searches, AlphaFold structures, enrichment analysis. Best for interactive exploration, simple queries. For batch processing or advanced BLAST use biopython; for multi-database Python workflows use bioservices.

GGUF format and llama.cpp quantization for efficient CPU/GPU inference. Use when deploying models on consumer hardware, Apple Silicon, or when needing flexible quantization from 2-8 bit without GPU requirements.

Submit and manage protocols on Ginkgo Bioworks Cloud Lab (cloud.ginkgo.bio), a web-based interface for autonomous lab execution on Reconfigurable Automation Carts (RACs). Use when the user wants to run cell-free protein expression (validation or optimization), generate fluorescent pixel art, or interact with Ginkgo Cloud Lab services. Covers protocol selection, input preparation, pricing, and ordering workflows.

Analyze and engineer protein glycosylation. Scan sequences for N-glycosylation sequons (N-X-S/T), predict O-glycosylation hotspots, and access curated glycoengineering tools (NetOGlyc, GlycoShield, GlycoWorkbench). For glycoprotein engineering, therapeutic antibody optimization, and vaccine design.

Interact with Gmail - search emails, read messages, send emails, create drafts, and manage labels. Use when user asks to: search email, read email, send email, create email draft, mark as read, archive email, star email, or manage Gmail labels. Lightweight alternative to full Google Workspace MCP server with standalone OAuth authentication.

Query gnomAD (Genome Aggregation Database) for population allele frequencies, variant constraint scores (pLI, LOEUF), and loss-of-function intolerance. Essential for variant pathogenicity interpretation, rare disease genetics, and identifying loss-of-function intolerant genes.

Interact with Google Calendar - list calendars, view events, create/update/delete events, and find free time. Use when user asks to: check calendar, schedule a meeting, create an event, find available time, list upcoming events, delete or update a calendar event, or respond to meeting invitations. Lightweight alternative to full Google Workspace MCP server with standalone OAuth authentication.

Interact with Google Chat - list spaces, send messages, read conversations, and manage DMs. Use when user asks to: send a message on Google Chat, read chat messages, list chat spaces, find a chat room, send a DM, or create a new chat space. Lightweight alternative to full Google Workspace MCP server with standalone OAuth authentication.

Interact with Google Docs - create documents, search by title, read content, and edit text. Use when user asks to: create a Google Doc, find a document, read doc content, add text to a doc, or replace text in a document. Lightweight alternative to full Google Workspace MCP server with standalone OAuth authentication.

Interact with Google Drive - search files, find folders, list contents, download files, upload files, create folders, move, copy, rename, and trash files. Use when user asks to: search Google Drive, find a file/folder, list Drive contents, download or upload files, create folders, move files, or organize Drive content. Lightweight integration with standalone OAuth authentication supporting full read/write access.

Read and write Google Sheets spreadsheets - get content, update cells, append rows, fetch specific ranges, search for spreadsheets, and view metadata. Use when user asks to: read a spreadsheet, update cells, add data to Google Sheets, find a spreadsheet, check sheet contents, export spreadsheet data, or get cell values. Lightweight integration with standalone OAuth authentication supporting full read/write access.

Read and write Google Slides presentations - get text, find presentations, create presentations, add slides, replace text, and manage slide content. Use when user asks to: read a presentation, create slides, find slides, add a slide, replace text in a presentation, or manage presentation content. Lightweight integration with standalone OAuth authentication supporting full read/write access.

Convert documents and text to audio using Google Cloud Text-to-Speech. Use this skill when the user wants to: narrate a document, read aloud text, generate audio from a file, convert text to speech, create a recording of documentation or analysis, create a podcast from a document, or use Google TTS/text-to-speech. Trigger phrases: "read this aloud", "narrate this", "create a recording", "text to speech", "TTS", "convert to audio", "audio from document", "listen to this", "generate audio", "go...

Post-training 4-bit quantization for LLMs with minimal accuracy loss. Use for deploying large models (70B, 405B) on consumer GPUs, when you need 4× memory reduction with <2% perplexity degradation, or for faster inference (3-4× speedup) vs FP16. Integrates with transformers and PEFT for QLoRA fine-tuning.

Expert guidance for GRPO/RL fine-tuning with TRL for reasoning and task-specific model training

High-performance toolkit for genomic interval analysis in Rust with Python bindings. Use when working with genomic regions, BED files, coverage tracks, overlap detection, tokenization for ML models, or fragment analysis in computational genomics and machine learning applications.

Query GTEx (Genotype-Tissue Expression) portal for tissue-specific gene expression, eQTLs (expression quantitative trait loci), and sQTLs. Essential for linking GWAS variants to gene regulation, understanding tissue-specific expression, and interpreting non-coding variant effects.

Control LLM output with regex and grammars, guarantee valid JSON/XML/code generation, enforce structured formats, and build multi-step workflows with Guidance - Microsoft Research's constrained generation framework

Query NHGRI-EBI GWAS Catalog for SNP-trait associations. Search variants by rs ID, disease/trait, gene, retrieve p-values and summary statistics, for genetic epidemiology and polygenic risk scores.