Data & Analytics

Audit, write, or revise renovate.json. Use when adding Renovate, troubleshooting unexpected (or missing) update PRs, hardening against supply-chain attacks, or evolving an existing config.

Comprehensive structure validation combining model-to-map analysis and unmodeled density detection

Best practices for protein structure refinement and validation in Coot. Use when performing (1) Residue refinement operations, (2) Model building and fitting, (3) Rotamer fixing, (4) Scripted/automated refinement workflows, (5) Validation and correlation checking.

RDKit molecular manipulation and visualization within Coot's Python environment. Use when working with Coot and need to (1) Create RDKit molecules from Coot monomers, (2) Modify molecular structures (e.g., atom substitution), (3) Generate 2D chemical structure diagrams, (4) Perform cheminformatics operations on ligands or small molecules loaded in Coot.

Query the PDBe (Protein Data Bank in Europe) REST API and Solr search API from within Coot to access structure metadata, validation data, revision history, search capabilities, and download coordinate files

Best Practices for Model-Building Tools and Refinement

Create interactive inline Chart.js graphs directly in the chat from live Coot data. Use this skill whenever the user asks to plot, graph, chart, or visualise any per-residue data from Coot — B-factors, density correlations, Ramachandran probabilities, rotamer scores, or any other per-residue metric. Also use when the user asks to overlay secondary structure on a graph, or to compare metrics across chains. Prefer this approach over any file-based graphing (e.g. Pygal) — it is faster, interacti...

Best practices for creating publication-quality molecular graphics figures in Coot using user-defined colors, ribbons, and molecular representations

API documentation to be loaded at startup - when starting a Coot session, immediately call get_function_descriptions() with the functions listed in this skill.

Using Density-Fit Correlations in Coot

How to handle Unmodelled Density Blobs

Best Practices for using Coot MCP

NCS Reference Guidance

When working with the Coot developer, focus on debugging and fixing issues, not workarounds

Search Grants.gov for federal funding opportunities by agency, category, and eligibility. 4 tools.

SEC EDGAR filings, BLS employment stats, and USDA crop prices. 3 tools for federal financial intelligence.

Pick which precise covariance estimator to use for a given dataset. Use when you have data X and are unsure which estimator fits its dimension, conditioning, or tail behavior. Wraps precise.suggest() and covariance_features().

Run Criterion benchmarks and detect performance regressions.

Generate time-windowed product pulse reports from configured signals.

Captures a new N|Solid diagnostic asset for a connected Node.js app. Use when the user explicitly asks to collect, capture, or generate a CPU profile, flamegraph, heap sample, heap snapshot, or heap tracking asset and wants it saved or handed off for analysis. For existing assets, use ns-analyze-asset instead.

invest系列主入口。识别标的类型，路由到专业分析工具。 触发：「分析一下」「看看这个」「值得买吗」「这只怎么样」「资产配置」「大师怎么看」「债券」「流动性」「市场环境」「比特币抄底」

invest系列：统一个股分析。覆盖A股/港股/美股，自动匹配分析模式。 快速判断：「分析这只股票」「看看XX公司」「这只股怎么样」「该不该买」「要不要卖」 美股量化：「分析AAPL」「美股」「NVDA」「价值投资」「ROE」「护城河」 深度研报：「深度分析」「DCF」「估值分析」「写个投资备忘录」「机构怎么看」「可比公司」「IC Memo」

invest系列：宏观与市场环境分析。评估全球流动性、美股情绪、加密底部信号，判断当前市场环境对风险资产是否友好。 触发：「流动性」「美联储」「缩表」「TGA」「SOFR」「MOVE」「日元套利」「钱紧不紧」「市场环境」 「美股情绪」「NAAIM」「市场过热」「恐惧贪婪」「仓位管理」「市场风险」「比特币抄底」「BTC底部」「MVRV」「抄底」

invest系列：基金分析。判断单一基金产品是否值得买入或持有：了解策略吗？能持续跑赢吗？成本合理吗？覆盖主动基金、ETF、指数基金、QDII。 触发：「分析这只基金」「ETF怎么样」「基金值得持有吗」「基金经理靠谱吗」「选哪只基金」