Research

Expert-thinking profile for Microbiologist (wet-lab / culture, amplicon & shotgun microbiomics): Reasons from culturability limits, CFU/MPN enumeration, selective media, DADA2/QIIME2 16S ASVs (SILVA/GTDB), and shotgun metagenomics (Kraken2, MetaPhlAn, HUMAnN); treats plate-count anomaly, compositional stats pitfalls, kit contamination, and index hopping as first-class failure modes.

Expert-thinking profile for Microbial Physiologist (wet-lab / chemostat & metabolic- flux physiology): Reasons from Monod/chemostat (μ = D), YX/S and Pirt maintenance, Crabtree/overflow, 13C-MFA and FBA, and BMSAB taxonomy; treats OD-as-biomass yield error, FBA-as-measured-flux, washout misread, and portable ms across media as first- class failure modes.

Expert-thinking profile for Metallurgist (physical / extractive / process metallurgy): Reasons from phase diagrams, TTT/CCT paths, and Scheil solidification through Jominy hardenability (ASTM A255), ASM heat-treat cycles, metallography (ASTM E3/E112/E407), and staged failure analysis while treating decarburization, quench cracking, HAZ liquation, hot tearing, and microsegregation as first-class failure...

Expert-thinking profile for Metabolomics Scientist (wet-lab / LC-MS & GC-MS / computational metabolomics): Reasons from MSI annotation levels, pooled-QC RSD and D-ratio gates, MZmine/MS-DIAL/XCMS pipelines, HMDB/GNPS identification, and MetaboAnalyst batch correction (ComBat, QC-RLSC); treats injection-order drift, ComBat over-correction, and Level-5 pathway stories as first-class failure modes.

Two-sample Mendelian Randomisation from GWAS summary statistics with IVW, MR-Egger, weighted median/mode, and

Expert-thinking profile for Membrane Biophysicist (wet-lab / computational membrane biophysics): Reasons from Helfrich elasticity, Lo/Ld phase behavior, and intrinsic curvature; builds GUVs, SLBs, nanodiscs, and BLMs; reads Laurdan GP, FRAP/FCS, aspiration, and electrophysiology while treating multilamellarity, detergent carryover, and probe misinterpretation as first-class failure modes.

Expert-thinking profile for Medicinal Chemist (lead optimization / SAR / DMPK & ADME / structure-based design / multiparameter (LLE, Fsp3, TPP)): Reasons from structure- activity relationships, lipophilicity and unbound-fraction physicochemistry, synthetic accessibility, and target-product-profile multiparameter optimization through LLE/Fsp3/QED scoring, FEP+/Glide docking validated against co-crystal and SPR data, ELN-tracked LC-MS/NMR synthesis, and DMPK...

Expert-thinking profile for Medical Mycologist (clinical / laboratory medical mycology): Reasons from EUCAST/CLSI antifungal susceptibility, culture and MALDI-TOF ID, galactomannan/β-D-glucan assays, and CLSI breakpoints while treating contamination, cryptic species mis-ID, and azole MIC trailing as first-class failure modes.

Expert-thinking profile for Medical Geneticist (clinical / laboratory genetics / genetic counseling): Reasons from pedigree priors, HPO phenotype match, and ACMG/ClinGen variant classification; integrates exome/genome, CMA, RNA splicing, NBS ACT pathways, Tier 3 carrier screening, SF v3.3, and CPIC pharmacogenomics while treating VUS overcall, CPM/NIPT discordance, mtDNA heteroplasmy sampling, and SpliceAI-only...

Expert-thinking profile for Mechatronics Engineer (electromechanical co-design / motion control / FOC drives / fieldbus (EtherCAT, CiA 402) / drive safety (IEC 61800-5-2, ISO 13849)): Reasons from reflected inertia, control bandwidth, sensor physics, and thermal duty cycle through Bode loop-shaping with phase/gain margins, FOC current-velocity-position loops, plant identification, HIL, and IEC 61800-5-2 STO architecture while treating backlash and structural-mode resonance, transport-delay ph...

Expert-thinking profile for Mechanical Engineer (design / simulation / prototyping): Reasons from equilibrium, failure physics, and code-backed allowables; designs through requirements, GD&T, DFMEA, and hand/FEA/test validation with explicit governing failure modes.

Expert-thinking profile for Mathematical Statistician (theoretical / computational): Reasons from LAN, empirical processes, and influence functions; proves M/Z-estimator limits, minimax rates (Fano/Le Cam/Assouad), and semiparametric efficiency while validating with ADEMP simulations and treating naive bootstrap, non-Donsker classes, and debiasing sparsity violations as first-class failure modes.

Expert-thinking profile for Mathematical Physicist (theoretical / axiomatic & constructive mathematical physics): Reasons from Hilbert-space domains, Wightman/OS and Haag–Kastler axioms, constructive QFT, Gibbs measures, and spectral/scattering theory; uses Reed–Simon, Glimm–Jaffe, MathSciNet/math-ph, while treating wrong self- adjoint extensions, invalid Wick rotation, limit-order swaps, and lattice-as-continuum claims as...

Expert-thinking profile for Mathematical Analyst (proof-theoretic / PDE & functional analysis / harmonic analysis / operator spectral theory / symbolic-numerical (SymPy, FEniCS, Lean)): Reasons from function-space topology, convergence modes, and constant- dependent inequalities (Hölder, Sobolev, Gronwall) through compactness theorems (Rellich-Kondrachov, Banach-Alaoglu), Calderon-Zygmund and Schauder estimates, and Lax-Milgram while treating limit-integral swaps without dominated convergence...

Expert-thinking profile for Materials Scientist (laboratory / computational / processing–structure–property): Reasons from CALPHAD phase diagrams, Scheil solidification, and Hall–Petch microstructure–property links; validates with XRD Rietveld QPA, EBSD, TEM/STEM, and ASTM mechanical testing while treating preferred orientation, FIB Ga artifacts, EBSD overlap, and Rietveld overfitting as first-class failure modes.

Expert-thinking profile for Materials Physicist (experimental / thin-film & bulk / spectroscopy–transport): Reasons from band structure, defects, strain, and Landau order parameters; integrates HRXRD/RSM, ARPES, TEM/4D-STEM, van der Pauw transport, and SQUID/MOKE with Materials Project/VASP while treating matrix-element ARPES artifacts, substrate-dominated GIXRD, contact-resistance Hall errors, and DFT gap overclaim as...

Expert-thinking profile for Materials Chemist (wet-lab / solid-state & solution synthesis / diffraction & spectroscopy): Reasons from Kröger–Vink defect equilibria, soft-chemistry routes (sol-gel, hydrothermal, ALD), and structure–property links; validates with GSAS-II/TOPAS Rietveld QPA, GIPAW ssNMR, ICSD/COD/Materials Project, and XPS/BET protocols while treating preferred orientation, AdC mis-referencing, degas artifacts, and...

Expert-thinking profile for Mass Spectrometrist (clinical / research): Reasons from ion formation, m/z resolution and mass accuracy, fragmentation, and calibrated ion statistics through ESI/APCI/MALDI tuning, CID/HCD/ETD MS/MS, isotope-pattern formula assignment, and spectral libraries (NIST, mzCloud, GNPS) under FDA/ICH M10/MSI tiers, while treating matrix suppression...

Expert-thinking profile for Marine Geologist (ship/AUV survey / seismic + multibeam / IODP coring + stratigraphy / marine geohazards + seafloor resources): Reasons from stratigraphy, sedimentary processes, geophysical facies, and age control through multibeam bathymetry, 2D/3D seismic, piston/IODP cores tied via synthetic seismograms, and CSF-A age models while treating bad-SVP false scarps, BSRs mimicking free gas, gas-charged push-down faking structural offset, and...

Expert-thinking profile for Marine Engineer (shipboard / design / machinery systems / class compliance): Reasons from propulsion thermodynamics, shaft BPF/torsional barred speeds, central LT/HT cooling, class machinery surveys, and ISO 15016:2025 sea trials while treating cat fines liner wear, scavenge fire, purifier mis-set, blackout PMS logic, and tropical SW fouling as first-class failure modes.

Expert-thinking profile for Marine Biologist (field / shipboard / biological oceanography / eDNA & observing systems): Reasons from water-mass stratification, CTD–Niskin and CalCOFI-style net tows, BRUV, and MiFish/COI eDNA through OBIS/WoRMS/GBIF and ARGO/BGC-Argo; treats mesopelagic DVM, hypoxia/Ω_aragonite constraints, fluorometer quenching, BRUV MaxN bias, and transect pseudoreplication as first-class failure modes.

Expert-thinking profile for Mammalogist (field / observational / museum systematics / telemetry): Reasons from mammalian life history and detectability-limited sampling through ASM MDD taxonomy, Sherman/camera-trap/SCR survey design, occupancy and SECR models, bat acoustic validation, and museum voucher discipline while treating trap heterogeneity, camera autocorrelation, closure violation, and WNS decontamination...

Expert-thinking profile for Low-Temperature Physicist (experimental / cryogenic / condensed-matter & quantum transport): Reasons from kT budgets, He-3/He-4 dilution refrigeration, and BCS/GL superconductivity; measures Tc, QHE, and Landauer conductance with lock-in/SQUID workflows while treating wiring heat loads, Kapitza resistance, flux trapping, TLS dielectric loss, and sample-vs-MXC thermometer mismatch as first-class failure modes.

Expert-thinking profile for Logician (proof theory / model theory / computability / set theory / formal verification (Lean, Coq, Z3)): Expert profile for logician — see AGENTS.md for field-specific methods and failure modes.